IPC04: Guideline for the Isolation of Patients

Key Points

  • This guideline focusses on the placement of patients in single rooms for infection prevention and control reasons (source and protective isolation).

  • Isolation facilities should be prioritised depending on the known/suspected infectious agent.

  • All patient placement decisions and assessment of infection risk (including isolation requirements) must be clearly documented in the patient notes and provided in communication with other healthcare/ care providers.

  • This guideline should be used as a supplement to the guidance within the National Infection Prevention & Control Manual for England.

Version:19.1
Date Issued:07/04/2025
Review Date:01/04/2027
Key words:Isolation; Source; Protective; Precautions; Contact; Respiratory; Prioritisation

This is a controlled document. If you are using a printed copy, check it against the guidelines site to ensure you are using the latest edition. Print copies must be destroyed after use.

Abbreviations

ADTAdmissions, Discharges and Transfers
BPBlood Pressure
CDIClostridioides Difficile Infection
CPECarbapenemase-Producing Enterobacterales
FPHFrimley Park Hospital
HPTHealth Protection Team
HCWsHealthcare workers
IPCTInfection Prevention and Control Team
paICEElectronic Pathology Reports
MDROMulti-Drug-Resistant Organism
MRSAMethicillin-resistant Staphylococcus aureus
PPEPersonal Protective Equipment
WPHWexham Park Hospital

1. INTRODUCTION

There are four main reasons that patients are cared for in single room accommodation within the Trust:

  1. To isolate a known or suspected infectious agent to reduce the risk of its transmission to between patients (source isolation)

  2. To reduce the risk of infection transmission to patients susceptible to infection (protective isolation)

  3. Clinical but not infection-related reasons

  4. Non-clinical reasons (for example patient preference)

This guideline focusses on the placement of patients in single rooms for infection prevention and control reasons (namely source and protective isolation), to minimise the risk of infection transmission within the healthcare setting.

This guideline should be used as a supplement to the guidance within the National Infection Prevention & Control Manual for England.

2. RISK ASSESSMENT

2.1 The potential for transmission of infection must be assessed at the patient’s entry to the care area. Completion of the Communicable Disease screening tool on Epic will provide a record of the assessment of risk, and if the patient is hospitalised, this risk should be continuously reviewed throughout the inpatient stay/episode of care. The assessment should influence placement decisions in accordance with clinical/care need(s). Patients who may present a cross-infection risk in any setting includes those:

• with diarrhoea, vomiting, an unexplained rash, fever, or respiratory symptoms

• known to have been previously positive with a Multi-Drug-Resistant Organism (MDRO) eg. MRSA, CPE

• who have been an inpatient in any hospital in the UK or abroad or are a known epidemiological link to a carrier of CPE

• who have a known or suspected infection or colonisation

2.2 Isolation facilities should be prioritised depending on the known/suspected infectious agent (refer to NHS England IPC A to Z of Pathogens Resource, and Appendix B for local prioritisation). When there are competing demands for single rooms, the Site Managers and Infection Prevention & Control Team (IPCT) should jointly agree on the appropriate placement of patients.

2.3 All patient placement decisions and assessment of infection risk (including isolation requirements) must be clearly documented in the patient notes.

2.4 If single rooms are limited, patients who have conditions that facilitate the transmission of infection to other patients (eg. draining wounds, stool incontinence, uncontrolled cough, uncontained secretions) and those who are at increased risk of acquisition and adverse outcomes resulting from healthcare-associated infections (e.g. immunosuppression) should be prioritised for placement in a single rooms.

2.5 The clinical judgement and expertise of the staff involved in a patient's management and the IPCT should be sought particularly when there are competing demands for single room accommodation.

2.6 Patient records should be reviewed for information of current or historical infection risks.

2.7 Cohorting of patients with specific infections must not take place unless on advice from the IPCT.

2.8 Healthcare workers (HCWs) caring for patients in their own home must ensure they are aware why patient is in isolation and the precautions required for that scenario. The HCW must risk assess if any PPE is required. IPC precautions will be dependent on the reason for isolation, and standard IPC precautions apply for all care. Clear communication for all relevant parties is essential.

3. TYPES OF ISOLATION ROOM

3.1 Single room with no en-suite facilities These rooms can be used for source isolation if rooms with en-suite facilities are unavailable. If enteric precautions are required, toilet facilities such as a commode will need to be designated for use in the room. These rooms are most appropriate for patients who require a single room for non-IPC reasons.

3.2 Single room with en-suite facilities These rooms are suitable for isolation of infections spread by contact, enteric route, or respiratory route (if rooms with an anteroom are unavailable). These rooms are also suitable for patients requiring protective isolation.

3.3 Single room with en-suite facilities, plus anteroom (neutral pressure) These rooms are prioritised for infectious diseases transmitted via the respiratory route, as the anteroom can be used for donning of PPE required.

3.4 Negative pressure isolation room (en-suite and positive pressure anteroom) These rooms are prioritised for infectious diseases transmitted via the respiratory route (pulmonary tuberculosis, influenza, measles, novel coronaviruses), and High Consequence Infectious Diseases awaiting transfer to a High-Level Isolation Unit (eg. Viral Haemorrhagic Fever). There are a small number of negative pressure isolation rooms on the WPH (ICU and EAC) and FPH sites (ICU and ward G1).

3.5 Positive pressure isolation room These rooms are prioritised for patients requiring protective isolation. This room type is not currently available at Frimley Health.

4. CATEGORIES OF ISOLATION

Source IsolationProtective Isolation
Reason for isolationTo protect other patients and staff. This is used to prevent infections
for which the route of transmission is often direct contact with the
patient and patient’s body fluids (faeces, urine, secretions or blood)
or indirect contact, via patient’s immediate care environment
(including care equipment).
To protect a patient who is severely clinically vulnerable
to infection (eg. severe immunosuppression, multiple
burns, un-vaccinated children)
Standard IPC Precautions
(including hand hygiene)
Applies to all careApplies to all care
Transmission-Based
Precautions
Contact precautions

Used to prevent and control infections that spread via direct
contact with the patient or indirectly from the patient’s
immediate care environment (including care equipment).
Includes enteric precautions (organisms transmitted by the
faecal-oral route (i.e. Clostridium difficile)).

Respiratory precautions

Used to prevent and control infections that spread
via the respiratory (droplet and airborne) route.


Refer to NHS England IPC A to Z of Pathogens Resource,
and IPC28a: Personal Protective Equipment Use for Infection
Prevention and Control for further information.
N/A
Door Sign (the correct
coloured card must be
displayed clearly on the
outer side of the door
to the room)

Appendix A
Red

Blue


In the instance that a patient requires both Source and Protective Isolation (eg. a severely immunosuppressed patient who has a Clostridium difficile Infection),
a Red ‘warning card’ must be displayed.

The door of the isolation room should be closed at all times, aside from entry and exit. If the ward has concerns that the patient is unable to have the door closed
(and therefore is unable to be isolated), they must put in place extra measures to prevent the cross transmission and entry of unnecessary visitors or non-essential
staff, like prominent visible place for the ‘Warning’ sign, PPE station close to the entrance of the room, close supervision of the patient, or contact the IPCT for advice.
Personal Protective
Equipment
Standard IPC precautions apply.

Refer to IPC28a: Personal Protective Equipment Use for
Infection Prevention and Control for PPE guidance
for transmission-based precautions.


All PPE must be removed, disposed of, and hands
cleaned before leaving the isolation room (excluding
respiratory protective equipment, which should be
removed immediately on exiting the room, and
hands cleaned).
Standard IPC precautions apply.

Any PPE used must be removed, disposed of,
and hands cleaned before leaving the isolation
room
Equipment required
for the room
This should be kept to the minimum possible, to enable access
for cleaning, and to reduce wastage of disposable equipment on
patient discharge/ resolution of infection.


Where possible, patient equipment (eg. BP cuffs, manual handling
equipment) should be dedicated for that patient’s use.

The following equipment should be available for the room, as a minimum:

• Alcohol-based hand sanitiser

• Liquid soap and paper towels at the hand hygiene sink

• Personal protective equipment (suitably dispensed).


• Commode/ bedpan as required (if en-suite facilities are not available)

• Mop handle and bucket

• Thermometer, BP cuff

• Infectious clinical waste bin and orange bags

• Water-soluble (alginate) linen bags
Notes & ChartsEpic electronic equipment should be kept outside of the room where possible. If taken into the room, surfaces should be
decontaminated after use.
Waste and Linen
• Waste must be disposed of in the infectious clinical waste stream.

• Used linen must be secured in an alginate bag within the room,
prior to placing in a white outer bag.
Standard IPC precautions apply.
DecontaminationRefer to IPC28b: Decontamination and Management of the Care Environment for details on terminal and deep cleaning.
Staffing
• Staff entering the room should be kept to the minimum necessary to care for the patient.

• Staff must not enter the room if they have an infectious disease themselves.

• Staff must be aware of their vaccination to relevant infectious diseases prior to entering the room.

• Consider assigning a dedicated team of care staff to care for patients in isolation/cohort
rooms/areas as an additional infection control measure during outbreaks/incidents.
VisitorsVisitors should report to the nurse/midwife-in-charge before entering the isolation room, and in addition also be advised:


• To clean hands before and after visiting.

• If any PPE is required during their visit (PPE is not usually required for routine visiting)
CommunicationThe patient requiring isolation must be provided with information on the rationale for isolation, isolation procedures
and treatment, and provide the relevant Patient Information leaflet, available via Ourplace.

Contact a member of the IPCT if detailed information on their condition/ infection is required. Record details of
information provided in the patient’s notes and clearly state the reasons. Epic care pathways for MRSA, CDI
and CPE should be used to document care relating to these specific conditions.
Patient wellbeingWhilst some patients prefer to receive care in a single room in hospital, some can find the requirement distressing
and socially isolating. It is of great importance that isolation does not compromise the patient’s care in hospital,
and psychological support and reassurance must be given to the patient whilst in isolation.

For patients in isolation, it is important that they are able to see staff from their beds. This reduces the psychological
problems of isolation. Staff should also be able to see the patient in case of emergency, and this can be facilitated
by the presence of observation windows.
Patient transferPatients requiring isolation should only be transferred if this is clinically necessary. Refer to IPC10: Guidelines for the
Transfer of Infectious Patients.

The receiving department/ health or social care setting, and transporting staff must be aware of any necessary precautions.
Discontinuation of isolationReview requirement for isolation daily.
Discontinuation of isolation based on
assessment of infection risk e.g.
resolution of symptoms, negative test
results, alternative diagnosis.
Review requirement for isolation daily. Discontinuation
of isolation is based on assessment of the level
of clinical vulnerability to infection.

5. COHORTING IN HOSPITAL SETTINGS

5.1 Cohorting of infectious patients can be considered, under the advice of the IPCT, when:

• demand for single room capacity outweighs availability, and if there are two or more patients (a cohort) with the same confirmed infection. Confirmation of infection must include microbiological confirmation (eg. two patients with confirmed SARS-CoV-2-positive PCR tests)

• there are situations of service pressure (eg. winter), and patients may have different or multiple infections. In these situations, the Trust preparedness plan must be in place ensuring that Organisation/Board level assurance on IPC systems and processes are in place (eg. IPC Board Assurance Framework).

5.2 Infectious patients who must not be cohorted with others with different or multiple infections include:

• those at increased risk of acquisition and adverse outcomes resulting from infection (eg. immunosuppression)

• individuals who are unlikely to comply with transmission-based precautions.

5.3 In the event of infection cohorting, the isolation practices in Section 4, apply to the cohort area, including the door to the cohort room/ area being kept closed. A minimum of one metre spacing must be maintained between patients within the cohort area.

6. MONITORING

Monitoring of this guideline if through the annual Infection Prevention & Control Environmental Audit programme.

References

Ayliffe, G.A.J., Collins, B.J., Lowbury, E.J.L., and Wall, M. (1971) ‘Protective isolation in single-bed rooms: studies in a modified hospital ward’, Journal of Hygiene (London), 69(4), pp. 511-527. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2131037/pdf/jhyg00090-0006.pdf (Accessed: 18 January 2024).

Royal College of Nursing (2017) Essential practice for infection prevention and control: guidance for nursing staff. Available at: https://www.rcn.org.uk/-/media/royal-college-of-nursing/documents/publications/2017/november/pub-005940.pdf?la=en (Accessed: 18 January 2024).

Department of Health & Social Care (2022) The Health and Social Care Act 2008: code of practice on the prevention and control of infections and related guidance. Available at: https://www.gov.uk/government/publications/the-health-and-social-care-act-2008-code-of-practice-on-the-prevention-and-control-of-infections-and-related-guidance/health-and-social-care-act-2008-code-of-practice-on-the-prevention-and-control-of-infections- (Accessed: 18 January 2024).

Department of Health (2013a) Health Building Note 00-09: infection control in the built environment. Available at: https://www.england.nhs.uk/wp-content/uploads/2021/05/HBN_00-09_infection_control.pdf (Accessed: 18 January 2024).

Department of Health (2013b) Health Building Note 04-01: supplement 1: isolation facilities for infectious patients in acute settings. Available at: https://www.england.nhs.uk/wp-content/uploads/2021/05/HBN_04-01_Supp_1_Final.pdf (Accessed: 18 January 2024).

Department of Health (2013c) In-patient care: Health Building Note 04-01: adult in-patient facilities. Available at: https://www.england.nhs.uk/wp-content/uploads/2021/05/HBN_04-01_Final.pdf (Accessed: 18 January 2024).

NHS England (2023) National infection prevention and control manual (NIPCM) for England. Available at: https://www.england.nhs.uk/national-infection-prevention-and-control-manual-nipcm-for-england/ (Accessed: 18 January 2024).

Siegel, J.D., Rhinehart, E., Jackson, M., Chiarello, L., and the Healthcare Infection Control Practices Advisory Committee (2007) Guideline for isolation precautions: preventing transmission of infectious agents in healthcare settings. Available at: https://www.cdc.gov/infectioncontrol/guidelines/isolation/index.html (Accessed: 18 January 2024).

APPENDIX A: Isolation ‘Warning’ Signs

APPENDIX B: Essential Source Isolation Prioritisation & Actions

Full version control record

Version:19.1
Guidelines Lead(s):Victoria Gentry (Infection Prevention Nurse Consultant) & Dr Manjula Meda (Consultant Microbiologist/ Infection Control Dr)
Contributor(s):Frimley Health IPC Working Group
Lead Director / Chief of Service:Melanie Van Limborgh (Chief of Nursing & Midwifery/ Director of Infection Prevention & Control)
Library check completed:18/01/2024
Ratified at:Healthcare Infection Control Committee 24/04/2024
Date Issued:08/04/2025
Review Date:01/04/2027
Pharmaceutical dosing advice and formulary compliance checked by:N/A
Key words:Isolation; Source; Protective; Precautions; Contact; Respiratory; Prioritisation

This guideline has been registered with the Trust. However, clinical guidelines are guidelines only. The interpretation and application of clinical guidelines will remain the responsibility of the individual clinician. If in doubt, contact a senior colleague or expert. Caution is advised when using guidelines after the review date. This guideline is for use in Frimley Health NHS Foundation Trust hospitals only. Any use outside this location will not be supported by the Trust and will be at the risk of the individual using it.

Version History

VersionDateGuideline Lead(s)StatusComment
16.019/08/2021Infection Prevention Nurse, Consultant Dr, Consultant Microbiologist / Infection ControlFinal
17.003/02/2022Clinical Guidelines AdministratorFinalTransferred to new Guideline Template
18.030/09/2022Infection Prevention Nurse, Consultant Dr, Consultant Microbiologist / Infection ControlFinalRatified at HICC, January 2023
19.015/1/2024Infection Prevention Nurse, Consultant Dr, Consultant Microbiologist / Infection ControlFinalApproved at HICC, 24/4/2024
19.108/04/2025Infection Prevention Nurse, Consultant Dr, Consultant Microbiologist / Infection ControlInterimUpdated Appendix B

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